Depression is a mood disorder. The definition in this protocol is consistent with the DSM-IV-TR (APA, 2000). Unless specified, the term “depression” encompasses both major depressive disorder (MDD), dysthymic disorder (DD), depression NOS, adjustment disorder with depression or minor depression. Impairment means reduced functioning in one or more major areas of life: academic or performance, family relationships and peer interactions. it goes far beyond normal sadness or grief, causing persistent feelings of emptiness, loss of interest in activities, fatigue, and difficulty functioning in daily life.